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KMID : 0364920070320040178
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Journal of Radiation Protection and Research
2007 Volume.32 No. 4 p.178 ~ p.183
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Measurement of Growth Delay and the Oxygen Enhancement Ratio of Fast Neutron Beam Using Mouse Model System
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Eom Keun-Yong
Wu Hong-Gyun
Park Hae-Jin
Kwon Eun-Kyung
Ye Sung-Joon
Lee Dong-Han
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Abstract
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Neutrons are high LET (linear energy transfer) radiation and cause more damage to the target cells than x-rays or gamma rays. The damage from neutrons is generally considered fatal to a cell and neutrons have a greater tendency to cause cell death through direct interaction on DNA. We performed experiments to measure growth delay ratio and oxygen enhancement ratio (OER) in mouse model system. We inoculated EMT-6 cells to the right hind leg of BALB-c mouse and X-rays and neutron beams were given when the average volume of tumors reached $200-300mm^3$. We irradiated 0, 11, 15.4 Gy of X-ray and 0, 5, 7 Gy of fast neutron beam at normoxic and hypoxic condition. The volume of tumors was measured 3 times per week. In x-ray experiment, growth delay ratio was 1.34 with 11 Gy and 1.33 with 15.4 Gy in normoxic condition compared to in hypoxic condition, respectively. In neutron experiment, growth delay ratio was 0.94 with 5 Gy and 0.98 with 7 Gy, respectively. The OER of neutron beam was 0.97. The neutron beam was more effective than X-ray in the control of hypoxic tumors.
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KEYWORD
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Cyclotron, Mouse, Neutron, OER, Radiation therapy
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